As a senior researcher in the lab, I advise graduate students about experiments design for their corresponding projects. In addition I have my own projects as described hereafter.

Current projects:

1.    Using iPS cells to identify autoantigens involved in the pathogenesis of aplastic anemia. In this project I will use iPS cells derived from patients with aplastic anemia to generate hematopoietic cells suitable reconstitute the immune system of immunodefficient mice with the purpose of identify potential antigens that may be targeted by immune cells of patients with aplastic anemia.

2.    Identification of Non-HLA factors that influence the clinical outcomes of patients receiving hematopoietic stem cells transplantation for hematological malignancies. Using DNA samples from patients transplanted through the Japan Marrow Donor Program and taking advantage of the TaqMan genotyping technique, I look for genetic variants on genes involved in the immune response, as well on cell metabolism and their influences on transplant outcomes. Current gene targets are CISH, CD53, NLRP3, IDH1 and others.

3.    Identification of new pharmacological agents that may useful for the treatment of refractory leukemia. By using a panel of 25 leukemia cell lines and primary leukemia cells derived from patients, I am investigating the therapeutic potential of novel agents (preferentially non cytotoxic drugs) against refractory leukemias. These studies have allowed to identify some agents with attractive potential such as benfotiamine, Gnetin C, thymoquinone and others.

金沢大学第三内科／血液・移植グループ：インデックス へ

血液凝固検査入門（図解シリーズ）へ
播種性血管内凝固症候群（DIC）（図解シリーズ）へ
金沢大学血液内科・呼吸器内科HPへ
金沢大学血液内科・呼吸器内科ブログへ
研修医・入局者募集へ

参考：血栓止血の臨床（日本血栓止血学会HPへ）